Surgery "better than chemotherapy" for tongue cancer
tongue cancer surgery
oral cancer stages
tongue cancer causes /Why is tongue cancer produced? Tongue Cancer
For the treatment of cancer, many would consider chemotherapy as the best option. But for cancer of the tongue, new research suggests that surgery may be the most effective primary care port. This is according to a study published in the journal JAMA Otolaryngology Head and Neck Surgery.
According to the American Cancer Society, approximately 36,000 people will have been diagnosed with cancer of the oral cavity or oropharynx, which includes cancer of the tongue, in the United States. UU Throughout 2013.
The main treatment options for people with oral and oropharyngeal cancer include surgery (partial or total removal of the tongue for tongue cancer, followed by extensive reconstruction), radiation therapy, chemotherapy, targeted therapy and palliative treatment. These can be used alone or in combination.
But researchers at the University of Michigan Comprehensive Cancer Center, including Dr. Douglas Chepeha of the University of Michigan School of Medicine, say that patient outcomes could be improved if surgery were used as the first choice. treatment.
"For a young person with cancer of the tongue, chemotherapy may sound like a better option than surgery with extensive reconstruction," says Dr. Chepeha.
"But patients with oral cavity cancer can not tolerate induction chemotherapy as well as they can manage surgery with follow-up radiation, our reconstruction techniques are advanced and offer patients better survival and functional results."
Poor results of patients with induction chemotherapy
To arrive at their findings, the researchers first analyzed 19 patients with advanced cancer of the oral cavity.
All patients had induction chemotherapy. Patients with a poor response to chemotherapy underwent surgery followed by radiation therapy, while patients whose cancer was reduced by 50% received additional chemotherapy in combination with radiation therapy.
Of the 10 patients who responded to chemotherapy, only three had a complete response and had no cancer 5 years after treatment.
Of the other nine patients who received surgery after induction chemotherapy, only two had no cancer and were alive after 5 years.
Then, the researchers analyzed a comparable group of patients, all of whom underwent surgery as initial treatment followed by radiation therapy. According to the researchers, this group observed better survival rates and functional results.
The research team says the findings are contrary to protocols for the treatment of laryngeal cancer, in which they say that a dose of chemotherapy can help doctors determine which patients respond best to chemotherapy and radiation, and what Patients can have better results with surgery.
The researchers point out that for laryngeal cancer, induction chemotherapy usually leads to better patient survival and functional outcomes, as they discovered in their own previous research. But they say their findings show that this is not the case with tongue cancer.
For the treatment of cancer, many would consider chemotherapy as the best option. But for cancer of the tongue, new research suggests that surgery may be the most effective primary care port. This is according to a study published in the journal JAMA Otolaryngology Head and Neck Surgery.
According to the American Cancer Society, approximately 36,000 people will have been diagnosed with cancer of the oral cavity or oropharynx, which includes cancer of the tongue, in the United States. UU Throughout 2013.
The main treatment options for people with oral and oropharyngeal cancer include surgery (partial or total removal of the tongue for tongue cancer, followed by extensive reconstruction), radiation therapy, chemotherapy, targeted therapy and palliative treatment. These can be used alone or in combination.
But researchers at the University of Michigan Comprehensive Cancer Center, including Dr. Douglas Chepeha of the University of Michigan School of Medicine, say that patient outcomes could be improved if surgery were used as the first choice. treatment.
"For a young person with cancer of the tongue, chemotherapy may sound like a better option than surgery with extensive reconstruction," says Dr. Chepeha.
"But patients with oral cavity cancer can not tolerate induction chemotherapy as well as they can manage surgery with follow-up radiation, our reconstruction techniques are advanced and offer patients better survival and functional results."
Poor results of patients with induction chemotherapy
To arrive at their findings, the researchers first analyzed 19 patients with advanced cancer of the oral cavity.
All patients had induction chemotherapy. Patients with a poor response to chemotherapy underwent surgery followed by radiation therapy, while patients whose cancer was reduced by 50% received additional chemotherapy in combination with radiation therapy.
Of the 10 patients who responded to chemotherapy, only three had a complete response and had no cancer 5 years after treatment.
Of the other nine patients who received surgery after induction chemotherapy, only two had no cancer and were alive after 5 years.
Then, the researchers analyzed a comparable group of patients, all of whom underwent surgery as initial treatment followed by radiation therapy. According to the researchers, this group observed better survival rates and functional results.
The research team says the findings are contrary to protocols for the treatment of laryngeal cancer, in which they say that a dose of chemotherapy can help doctors determine which patients respond best to chemotherapy and radiation, and what Patients can have better results with surgery.
The researchers point out that for laryngeal cancer, induction chemotherapy usually leads to better patient survival and functional outcomes, as they discovered in their own previous research. But they say their findings show that this is not the case with tongue cancer.
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